Yesterday we began to look at an email conversation I had recently with Jasia from The Creative Gene about genetic genealogy.
Jasia began by asking whether she should test both her and her mother’s mtDNA (I advised her no, because they would be the same sequence), and then we talked about testing her father’s mtDNA. Since her father could not be tested directly, Jasia wondered if her brother could provide a sample of her father’s mtDNA. I explained that although her brother could provide a sample of her father’s Y-DNA, she would have to find other sources for her father’s mtDNA, including her father’s sisters or brothers, or the children of her father’s sisters. She responded:
“Fortunately, my dad came from a large family including 6 sisters 4 of which had children. … Click to read more!
This week I had a terrific email conversation with Jasia from The Creative Gene about genetic genealogy. She left a comment on a recent post, Discovering My Maternal Roots, which asked:
â€œIâ€™m a complete neophyte about DNA for genealogy. Iâ€™m wondering if there is any reason to test myself, and my mother. Since the mtDNA seems to trace the maternal lineâ€¦ is it enough to test just one of us or is there something to be learned by testing both of us?â€
This is a great question, one that many people who are new to genetic genealogy ask. Understanding how mtDNA and Y-DNA are inherited is one of the most challenging aspects of genetic genealogy. I always think of them as mirror images; if you chart your family tree, the Y-DNA travels down the far left line (from … Click to read more!
Although the article in today’s New York Times – “DNA Tests Offer Immigrants Hope or Despair” by Rachel L. Swarns – uses traditional paternity or maternity tests and not genetic genealogy tests, the emotional results of the tested can often be the same. What if DNA proves that your father isn’t your biological father? What happens when there is uncontestable proof that there was an NPE (non-paternal event) in your great-grandfather’s ancestry?
According to the article, federal officials in the Immigration Department are using “genetic testing to verify the biological bonds between new citizens and the overseas relatives they hope to bring here, particularly those from war-torn or developing countries where identity documents can be scarce or doctored.”
For example, Isaac has … Click to read more!
I get visitors from search engines nearly everyday looking for information about the startup business 23andMe. Iâ€™ve briefly mentioned 23andMe before, but I thought Iâ€™d see how much information I could gather doing a brief online search.
The website describes the venture:
â€œ23andMe is an early stage startup developing tools and producing content to help people make sense of their genetic information. Our goal is to take advantage of new genotyping technologies and help consumers explore their genetics, informed by cutting edge science.
â€œCombining computer science, biology and informatics, we are at the cutting edge of a new era of genetics. Genome deciphering technologies have reached affordable levels, allowing consumer access. This information … Click to read more!
Here are some recent news articles that mention the use of genetics in traditional … Click to read more!
I recently profiled the website DnaTube which hosts videos and animations that explain various facets of genetics and DNA. Another source of valuable information is the Learn.Genetics website hosted by the Genetic Science Learning Center at the University of Utah.
According to the website:
“The Genetic Science Learning Center is an outreach education program located in the midst of bioscience research at the University of Utah. Our mission is to help people understand how genetics affects their lives and society. Our educational resources provide accurate and unbiased information about topics in genetics and bioscience. Designed for non-research audiences, our materials are interactive and jargon-free, target multiple learning styles, and often convey concepts through … Click to read more!
An article in today’s New York Times, “Stalking Strangers’ DNA to Fill in the Family Tree” by Amy Harmon, looks at the extremes that some genetic genealogists have gone to to ‘obtain’ DNA from other people for analysis. The genetic genealogists in the article have stalked potential relatives and one keeps a DNA kit in his fridge awaiting his uncooperative father’s demise.
I recently asked my father’s first cousin to take a DNA test since he possessed the only surviving mtDNA from my great-grandmother, and orphan. The two lines had connected in 30 or 40 years, but once I made contact he was very interested in taking the test. The results provided the only clues I have regarding my great-grandmother’s ancestry. If that source had been unwilling to participate, I own some letters that my … Click to read more!
I just happened across a new site called DnaTube.com Scientific Video Site. According to the website:
“DnaTube is a scientific research site providing video based studies, lecturers and seminars. Our goal is to contribute science by generating self-growing community who shares their scientific experiences. Most of DnaTube members are graduate students from universities of all countries.”
There’s a very brief introduction to DNA, genes, and inheritence.Â Even better, I watched a FASCINATING video showing the 3D structure of a mitochondria.Â For anyone who’s purchased a mtDNA genealogy test, this is a great video to understand more about mitochondria. I also watched a very cool video about red blood cells.
It looks as thought DnaTube is just starting, so check back often to see … Click to read more!
The CCR5 gene encodes a chemokine receptor (a long name for a protein that sits in the walls of our cells). When the body has been invaded by a pathogen such as a cold virus, CCR5 plays an important role in fighting that virus. Smart viruses such as HIV-1, however, hijack the CCR5 protein and use it to sneak into CD4+ T cells & macrophages.
In some populations the CCR5 gene has experienced a mutation that deleted 32 basepairs in the gene sequence. The mutation prevents the expression of the protein on the cell surface. As a result, people with this mutation show some degree of protection from certain viruses. In fact, homozygosity of the CCR5-D32 allele (meaning BOTH copies of the gene are mutated) leads to “nearly complete … Click to read more!
My first foray into genetic genealogy took place in 2003 when I ordered the mtDNAPlus (which sequences both HVR1 and HVR2) from Family Tree DNA.
Like so many other genealogists, I had been unable to trace my maternal line as far as I would have hoped. My most distant ancestor, Sarah L. Bodden, was born in 1846 in the Cayman Islands and had died in 1914 in Honduras. No one knew anything about Sarahâ€™s parents or her life, and given the location and the difficulty of research I felt that this line had little prospect of development. It was a perfect opportunity to employ genetics.
Inside (almost) every one of my 50 trillion cells (thatâ€™s 50,000,000,000,000!!!) there is a tiny circle of DNA that has been given to me, most likely … Click to read more!