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Ancestral GPS – Pinpointing the Geographic Origin of Autosomal DNA Sequences

image I’ve been meaning to write about recent two papers, one in Current Biology and one in Nature, that attempt to identify and characterize a relationship between genetic sequence or SNP and geography.  Amazingly, both papers found a very strong correlation between genetics and geography. From a news article regarding the paper in Nature (note that I haven’t verified that the paper supports the statement; HT: Yann Klimentidis’ Weblog):

"The map was so accurate that when Novembre’s team placed a geopolitical map over their genetic "map", half of the genomes landed within 310 kilometres of their country of origin, while 90% fell within 700 km."

Although there are some caveats, for example in one of the papers all of an individual’s grandparents had to have similar geographic origins in order for the method to identify ancestry, these types of studies will continue to discover and refine the methods and findings.  As Kambiz stated at Anthropology.net, "With higher resolution GeneChips, ideally full genomes, and larger samples, … Click to read more!

Dick Eastman Interviews The Genetic Genealogist at FGS 2008

On September 5th at the 2008 Federation of Genealogical Societies Conference in Philadelphia, Pennsylvania, I was interviewed by Dick Eastman.  In the interview we discuss my blog, DNA testing in general, and my free ebook, “I Have the Results of My Genetic Genealogy Test, Now What?” (which is available for download in the sidebar of the blog).

If the player doesn’t appear in the post, the interview is available here (http://rootstelevision.com/players/player_conferences.php?bctid=1811559654).  It was a pleasure to meet and talk with Dick, and I hope you enjoy the … Click to read more!

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Genetic Genealogy Article in the Houston Chronicle

Journalist Maggie Greenhouse writes an entertaining article about genetic genealogy entitled “Who Do You Think You Are? Company Can Help Trace Genetic Ancestry” (Houston Chronicle, Sept. 19, 2008) .  Much of the article is about Oxford Ancestors (OA), a genetic genealogy company based in England, but the article also mentions some companies in the United States:

“Houston is also home to Family Tree DNA, a company that offers the same services as Oxford Ancestors. Last year, Harvard professor Henry Louis Gates joined forces with Family Tree DNA to help African Americans looking for answers about their past. AfricanDNA, the company Gates launched in November 2007, offers both genetic testing and genealogical tracing services for African Americans.”

Interestingly, the article mentions that OA databases have DNA from approximately 30,000 people.  By the way, I also noticed that the OA website has been completely redesigned.  It was a much needed update and looks … Click to read more!

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Gene Genie #37: Human Genomes Are a Dime a Dozen

image Welcome to the September 14, 2008 edition of Gene Genie!  Bloggers have begun to pick up posting with the end of summer, and it seems like everyday there’s a bunch of new interesting posts about the human genome.

96well at Reportergene presents “Trends in development of reporter genes.”  Reportergene is also looking for bloggers/reporters to join the blog’s community and help create the “main repository of news and tools for reportergenomists.”  See here for more information.

fightingfatigue presents » Have Japanese Researchers Found Diagnostic Tool for ME/CFS? posted at Fighting Fatigue.  According to a study discussed in the article, there might now be a test able to diagnose Chronic Fatigue Syndrome.

Genomes by the Handful

Human genomes are being sequenced by the handful these days.  Knome has recently delivered their first sequenced genomes to customers on 8gb USB drives placed in engraved boxes.  Additionally, news came last week that the first Arab genome had been … Click to read more!

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Follow-Up to 23andMe’s Price Drop

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Yesterday I wrote about 23andMe’s decision to lower their price to $399 (down from $999) while adding more genealogically-relevant SNPs and partnering with Ancestry.com.  Although I don’t have any further information about the new SNPs, I’ve seen a couple of interesting articles about the price drop around the blogosphere.

Aaron Rowe at Wired science writes “Human Genetics is Now a Viable Hobby.”  He notes that the new price is “well within the reach of cash-strapped grad students, frugal genealogy buffs and other not-so-early adopters.”  The comment thread is an interesting read as well.

“Cheap as chips”

Daniel MacArthur of Genetic Future writes “Cheap as chips: 23andMe slashes the price of personal genomics” at his new scienceblogs location.  Daniel also notes that the updated product “will certainly be popular with genetic genealogists” because of the addition of … Click to read more!

9

23andMe Lowers Price to $399 and Adds More Genealogical SNPs

logo 23andMe just announced that the price of their service has dropped from $999 to $399.  According to an article in the San Francisco Chronicle, the company lowered the price of testing to attract more customers and increase the size of their database.  The article maintains that 23andMe will still bring in profit from the lower membership price, which is made possible by a “new, higher-density gene-scanning chip made by Illumina Inc. of San Diego.”  From the press release:

“The new Beadchip, called the HumanHap550-Quad+, makes use of a four-sample format. 23andMe also has added improved custom content to the new Beadchip, which will include a broader range of Single Nucleotide Polymorphism (SNP) variations and rare mutations not found on the previous Beadchip, thereby providing more relevant data on published associations, as well as maternal and paternal ancestry.”

Since 23andMe launched nearly a year ago, I’ve said that genealogists are a huge potential market for 23andMe’s services.  Undoubtedly, the company has recognized the value of marketing their product to genealogists.  Indeed, 23andMe’s blog, the Spittoon, announced today that the company has partnered with Ancestry.com to provide … Click to read more!

6

Knome Delivers First Genomic Sequencing

Knome, a personal genomics company that launched within the past year, has just delivered the first genomic sequencing to customers according to a report in the MIT Technology Review.

After paying $350,000 for sequencing, customers receive their genetic sequence on an 8-gigabyte USB drive in an engraved silver box.  The USB is encrypted and contains special genome browsing software.

For the first time in history, it is unclear how many complete human genomes have been sequenced by scientists.  Prior to Knome, we knew exactly how many had been completed.  Now, and probably ever after, genomes will be sequenced and analyzed without all the typical fanfare and press releases.  Instead of just 2 or 3 genomes, there will soon be tens of genomes, then hundreds, and … Click to read more!

4

Interview with Forensic Genealogist Colleen Fitzpatrick, Ph.D. Part II

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Yesterday I posted the first part of a two-part interview with Colleen Fitpatrick, a forensic genealogist.  In that interview, we discussed Colleen’s participation in a project to identify the remains located at a military crash site from 1948.

Today, we discuss her work on identifying the Titanic’s Unknown Child, among other projects.

The Genetic Genealogist:  On April 17, 1912, two days after the RMS Titanic sank in the North Atlantic, the salvage vessel Mackay Bennett discovered the body of a young boy. The sailors paid for a monument, and the boy was buried in Fairview Lawn Cemetery in Halifax, Nova Scotia. In 2008, after an initial false identification based on dental records, the boy was identified as Sidney Leslie Goodwin. You were part of the … Click to read more!

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Interview With Forensic Genealogist Colleen Fitzpatrick, Ph.D.

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Colleen Fitzpatrick, Ph.D. is one of the most recognizable names in the field of forensic genealogy.  She has authored two books entitled Forensic Genealogy and DNA & Genealogy, and continues to make headlines in this fascinating field.  Here is just an excerpt from her biography, located at her website:

“Colleen Fitzpatrick, Ph.D., is the author of two of the best-selling books in genealogy.  Forensic Genealogy has been widely recognized for its innovative forensic science approach to genealogical research.  She has been featured on NPR’s Talk of the Nation radio program (July 2005), and has written cover articles for Internet Genealogy (June 2006), Family Tree Magazine (April 2006) and Family Chronicle (October 2005).  Colleen writes a regular column for Ancestry … Click to read more!

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Federation of Genealogical Societies Meeting

This Friday, September 5th, I’ll be attending the FGS meeting in Philadelphia.  I’m excited because this is my first big genealogy meeting (after 20 years of genealogy!), and because I get to sit and watch some great presenters discuss genetic genealogy.  The program is here.

I hope to meet some other genealogy bloggers, if any of you are planning to attend! … Click to read more!