Using DNA to Reunite the Clan Gregor

king-james-vi.jpg

James Stuart, known as King James VI in Scotland and King James the I in England and Ireland, issued an edict in 1603 that abolished the surname MacGregor and declared that everyone named MacGregor or Gregor must renounce the name or suffer death, all in response to the murder of the King’s Forester, who himself had hanged some MacGregors for poaching. A bounty of 1,000 merks (apparently a great deal of money) was placed on the heads of the clan leaders, with 100 merks for other members of the clan.

This the origin of Rob Roy, also known as Red MacGregor, or Robert Roy MacGregor. For the next 200 years The Clan Gregor endured this persecution. Men were killed while women and children were sold into slavery in the New World. Finally, in 1774, the Act of Proscription against the clan was repealed. ... Click to read more!

Border Reivers DNA Research

A study conducted by researchers at the Institute of Human Genetics at the Center for Life in Newcastle, England discovered that only 50% of males with the last name Robson can be traced back to a recent single ancestor.The research, commissioned to create a new exhibit called “The Robson Encyclopedia,” compared 12 markers from the Y-chromosomes of 100 male volunteer Robsons.

Apparently the Border Reiver clan of the Robsons in the Tyne Valley was notorious in the 1600’s and was made famous in a book called “The Steel Bonnets” by George MacDonald Fraser.According to one site:

“The term Border Reivers describes a number of English and Scottish families who fought a seemingly endless series of bloody confrontations from the 13th Century to the mid 17th Century. Sheep stealing and burning each other’s homes were part of everyday Border Reiver life – they were rugged, tough people who lived by their own laws.” ... Click to read more!

The Biggest Family Reunion Ever Based on Genetic Genealogy?

Yesterday The Jewish Press announced the “Kohen and Levi Conference: A Gathering of the Tribe.”The conference, to be held on July 15-19, 2007, is hosted in Jerusalem by The Center for Kohanim.The Center was founded in 1985 to “promote identity and knowledge among Kohanim the world over, and increase their feelings of awareness and commitment to their heritage as Kohanim.”The conference has a main page, a press release, and a brochure (pdf).According to the press release:

Recent scientific research and DNA testing has proven that today’s descendents of the biblical Kohanim are genetically related. Molecular geneticists have discovered the “Cohen Modal Haplotype” which is a Y- chromosome DNA lineage signature shared by a majority of both Ashkenazi and Sephardi Kohanim. This indicates a direct patrilineal descent of present-day Kohanim from a single ancient ancestor, genetically dated to have lived approximately 3,300 years ago, a time corresponding to the Exodus from Egypt. ... Click to read more!

The Spring 2007 issue of the Journal of Genetic Genealogy

In case my readers were not aware, the Spring 2007 issue of the Journal of Genetic Genealogy is now available. This free, open-access peer-reviewed journal has been around in the Spring of 2005 and offers recent news and analysis in the field of genetic genealogy. The current issue has the following articles:

A Funny Thing Happened on the Way to Retirement, By T. Whit Athey, editor
Discussion of recent developments in the field as well as nomenclature issues.

Stacking the Deck: Mutation Rate in the mtDNA Coding Region, By Ann Turner
According to the article, “Genetic genealogists, who are obtaining full-sequence mtDNA tests in increasing numbers, are in a position to provide a “biased sample” for the study of the mutation rate in the coding region.” ... Click to read more!

Famous DNA Review, Part II – Genghis Khan

In 2003, researchers from around the world released a paper that suggested that 8% of all Mongolian males have a common Y chromosome because they are the descendants of Genghis Khan (See “The Genetic Legacy of the Mongols,” 2003, Zerjal, et. al., American Journal of Human Genetics, 72: 717-721).The researchers examined the Y chromosome variability of over 2000 people from different regions in Asia and discovered a grouping of closely related lines.The cluster is believed to have originated about 1,000 years ago in Mongolia and its distribution coincides with the boundaries of the Mongol Empire.

Genghis Khan’s empire (he ruled from 1206 – 1227) stretched across Asia from the Pacific Ocean to the Caspian Sea and was reportedly extremely prolific.Khan’s son Tushi had as many as 40 sons.His grandson Kublai Khan is reported to have had as many as 22 sons, and perhaps many more.Together this family may have as many as 16 million descendants alive in Asia today.It is extremely important to note that until DNA can be extracted from Khan’s bones (which have never been found), there is no definitive proof that this Y chromosome cluster is actually descended from Genghis Khan. ... Click to read more!

Famous DNA Review, Part I – Thomas Jefferson

Thomas Jefferson, 3rd President of the United States, has been at the center of a DNA controversy for over 200 years.In September 1802 journalist James T. Callender wrote in Richmond Reporter that Jefferson had for many years “kept, as his concubine, one of his slaves.Her name is Sally [Hemmings].The name of her eldest son is Tom.His features are said to bear a striking though sable resemblance to those of the president himself.”Although these rumors had reportedly already been passed around quietly, this article spread the rumor far and wide, setting off many years of debate.

In 1998 analysis of a male descendant of Jefferson’s paternal uncle showed that Jefferson’ Y chromosome belonged to haplogroup K2 (Thomas Jefferson did not have any male descendants to provide DNA.For more information, see: “Jefferson fathered slave’s last child.” 1998. Nature 396 (6706): 27–28. PMID 9817200).Haplogroup K2 is rather rare, constituting just 1% of worldwide Y chromosomes (See “Thomas Jefferson’s Y chromosome belongs to a rare European lineage.” Am J Phys Anthropol 132(4): 584-9.PMID 17274013 ).Surprisingly, or perhaps not-so-surprisingly depending on which side of the debate you stood, a male descendant of Sally named Easton Hemmings possessed the same K2 chromosome, suggesting a genetic link between Jefferson and Easton.Keep in mind, however, that this is not determinative since it is possible that any of Jefferson’s male relatives (who possessed the same Y chromosome) could have fathered Easton.And keeping in mind that non-paternal events are ALWAYS a possibility, nothing is 100% certain.Not until we can time-travel and obtain DNA samples from the source! ... Click to read more!

Are aboriginal Australians and New Guineans the modern-day descendants of the extinct species Homo erectus?

Some scientists have hypothesized that Australian aboriginals received a portion of their DNA from an ancient hominid species called Homo erectus, which for a short time was contemporaneous with modern man. A recent study published in PNAS (Proceedings of the National Academy of the Sciences) set out to answer this question by analyzing mtDNA and Y-chromosome samples from aboriginals.

A total of 172 mtDNA and 522 Y-chromosome previously published and new sequences from aboriginal Australians and New Guineans were analyzed for mtDNA and Y-chromosome variation and were compared to the current world haplogroup tree. All of the mtDNA sequences were members of the M and N founder branches, and all of the Y-chromosome sequences fell into the C and F founder branches. ... Click to read more!

Genetic Genealogy in Iceland

Yesterday Science published a report from deCODE genetics in Iceland and a second report from academic colleagues in the United States and Canada that announced the discovery of a gene variant (a SNP) on chromosome 9p21 that results in an increased risk of heart attack (the abstracts are available online here and here). The SNP was discovered through genome-wide SNP analysis in Iceland and replicated in three groups of European descent in the United States. I don’t have access to either paper, but according to deCODE’s press release the variant is estimated to account for 20% of the incidence of heart attacks in Europeans, including one-third of early-onset cases (men and women age 50 to 60). Both companies used SNP Chips (that’s fun to say outloud), tiny gene chips that contain thousands and thousands of SNPs across the entire genome. Want to learn more about SNPs? Go to the SNP information page at the Human Genome Project. ... Click to read more!

Faces of Britain

face.jpg

In 2005 the Wellcome Trust established a £2.3 million project (roughly 4.5 million USD) at the University Oxford to examine the genetic makeup of the United Kingdom.The project would be led by the renowned geneticist and Oxford Professor Sir Walter Bodmer, joined by Oxford Professor Peter Donnelly (a population genetics and statistics expert) and the Wellcome Trust Principal Research Fellow Professor Lon Cardon.

The goal of the project is to establish a knowledge base for analyzing genes that are linked to disease.To do this, the researchers hoped to gather DNA from 3000 to 3500 volunteers throughout the UK who live in the same area as their parents and grandparents.Each volunteer’s DNA will be tested for 2000 SNPs (single nucleotide polymorphisms).The data will be combined with each volunteer’s medical history in the attempt to find a link between genetic make-up and the inheritability or susceptibility of a number of diseases such as diabetes and Alzheimer’s.The data will also be used to isolate DNA sequences that characterize the founders of each region of the UK, be they Viking, Saxon, or Celt. ... Click to read more!

Recent Genetic Genealogy News

Here are some recent news articles that mention the use of genetics in traditional genealogy:

  • Internet databases, DNA testing make genealogy an easy pursuit – but only for some – An Associated Press story about the use of DNA testing for people researching genealogy in countries (such as Asia, Africa, etc…) with few online databases.
  • Genes in fashion – The anthropology department of the California State University has tested the DNA of hundreds of students to create an exhibit called “Immigrants All! Our Migration Tales and Genetic Trails” in the department’s museum.
  • To Whom Else Does Your DNA Belong? – A response to reporter Amy Harmon’s recent story in the New York Times.Although I don’t agree with the strict opposition voiced in this student article, the title is very similar to the title I chose for my own response.
  • McCoy tempers in famed feud may have genetic cause – Many of the McCoy’s, one of America’s most famous feuding families, have a genetically inherited disease caused Von Hippel-Landau which cause tumors of the adrenal gland.This can lead to blood-pressure-meds.com and hot tempers.It turns out that geneticists have been studying and publishing about the family for over 30 years and have traced the disease through at least 4 generations.
  • Rogue-gene discovery could end family’s tragedy – Another story about using genetics and genealogy to trace the distribution of a devastating mutant gene through a family.This gene, which triggers stomach cancer, has ravaged at least 5 generations of a family in New Zealand.
  • ... Click to read more!