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The Genographic Project Public Participation Mitochondrial DNA Database

The Genographic Project is probably the largest genetic genealogy project in the world. For $99, the project will sequence seqments of either your mtDNA or your Y chromosome for addition into their publicly available database. The goal of the project, with ten research centers around the world, is to “map humanity’s genetic journey through the ages,” and to “address anthropological questions on a global scale using genetics as a tool.” There has been a huge response to this project, and they just released their first research paper using the results they have collected to date:

“Family Tree DNA is proud to announce that the first paper resulting from data collected through the Genographic Project has been published today at the PLOS GENETICS. “The Genographic Project Public Participation Mitochondrial DNA Database” can be found at http://genetics.plosjournals.org and it will be uploaded to the Family Tree DNA public library as well.

The paper resulted from the collaboration of the Genographic Project Scientific Team, Family Tree DNA Genomics Research Center, and the IBM Data Analytics Research Group.”

Results

This paper is all about the mtDNA sequences they have obtained through the project. In the first 18 months of the project, they have collected an amazing 78,590 mtDNA genotypes!! In the paper, … Click to read more!

DNA Testing Offered to Participants of the Slave Descendants Freedom Society Seminar Series


Two companies recently teamed up to offer their services to families with roots in the African Diaspora. Slave Descendants Freedom Society and Diversity Restoration Solutions are bringing a seminar series to 50 cities in the United States, Canada, and Europe titled “Restoring African American Families Using Genealogy and History.” The seminar will focus on topics such as slavery in America, the importance of African American family genealogy as it relates to slavery, and 13 steps to restoring a family with genealogy and history. According to a recent press release:

“This interactive seminar series is a stepping stone in that it seeks to help African Americans find their self identity, understand the benefits of restoring the core family base, and move forward in leveraging resources as a people,” said Sheppard, author of “Ancestor’s Call,” a genealogy and historical accounting of the Grandy family and Moses Grandy, an ancestor whose story was originally told in a rare 1843 slave narrative. “It’s important that we lay the foundation for generations coming after us; our children and grandchildren need to know who they are in order to receive their inheritance. This seminar honors the contributions of our ancestors but with an emphasis that this recognition should not occur just during Black History Month, but as a way of life, everyday. Participants will come away with a greater understanding of themselves, an action plan for tracing their family tree and hopefully a stronger appreciation for family and desire to pay it forward in their community.” A pdf brochure is available.

On Thursday, the two companies announced that they have partnered with Family Tree DNA to offer attendees of the Family Restoration Roundtable Educational Seminar series the opportunity to take a genetic genealogy test to learn more … Click to read more!

3

BRCA2 as a Cycle Path in Cambridge


Today represents a brief break from genetic genealogy, in a way, but I thought the topic was interesting enough to talk about.
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BRCA2 (Breast Cancer Type 2 susceptibility protein) is a tumor suppressor gene involved in the repair of DNA damage. BRCA2 binds to and regulates another protein (the product of the RAD51 gene) to fix DNA breaks caused by any number of factors. BRCA2 was discovered in 1995 by Professor Michael Stratton and Dr. Richard Wooster in cooperation with the Wellcome Trust Sanger Institute.
To date, researchers have identified 450 different mutations in the BRCA2 gene, some of which unfortunately cause an increased risk of cancer. Typically, the mutated gene produces an abnormally short protein that is unable to … Click to read more!

3

23andMe in the News

A June 18th article from MSNBC about online family trees and social networking revealed another tidbit about 23andMe. According to the article (and no source of the information is given), 23andMe “plans to charge $1,000 for an extensive genetic profile and features to help track down lost relatives.”

I’m not exactly sure what that means. Are distant cousins lost relatives? Or is the unknown birth mother of an adopted child a lost relative? Given 23andMe’s interest in genetic genealogy, I’m guessing that it’s for general interest, rather than just for people looking for birth parents. Or perhaps they’re doing both – it’s really not much of a difference. It’s all about building a database, of course. Without the ability to compare results to a database, the usefulness of DNA … Click to read more!

2

Interview with Katherine Hope Borges at ISOGG

The following is an interview with Katherine Hope Borges, founder of ISOGG (The International Society of Genetic Genealogy), done at the 2007 SoCal Genealogical Jamboree. ISOGG has about 5,000 members and is growing rapidly. ISOGG has MANY great services on their website, including the “Founding Fathers DNA Page”, and an up-coming Presidential DNA page.

If you liked the video, there are lots more at Roots Television!! If you’re interested in genetic genealogy and haven’t checked out Roots Television yet, you don’t know what you’re missing.

Thanks to Megan for letting me snag this … Click to read more!

Genetic Genealogy Used to Identify Lost Soldiers

An article in yesterday’s Mount Vernon News highlighted the use of genetic genealogy to identify POW’s from the Korean War who had died in North Korean detention facilities.
The Korean War Project, sponsored by the Department of Defense, uses genetic tests, especially mtDNA (because mtDNA is so hardy), to match remains to living family members. This type of identification has been used for years now.
One of the volunteers for the Project, Carol Kiley, has found 21 matches in the three months she’s been tracking down families. Ms. Kiley says that her background in genealogy helps her locate the families of missing soliders.
The article discusses the case of Pvt. Robert Wayne McNeil who served in F Company of the 7th Infantry … Click to read more!

12

Using DNA to Reunite the Clan Gregor

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James Stuart, known as King James VI in Scotland and King James the I in England and Ireland, issued an edict in 1603 that abolished the surname MacGregor and declared that everyone named MacGregor or Gregor must renounce the name or suffer death, all in response to the murder of the King’s Forester, who himself had hanged some MacGregors for poaching. A bounty of 1,000 merks (apparently a great deal of money) was placed on the heads of the clan leaders, with 100 merks for other members of the clan.

This the origin of Rob Roy, also known as Red MacGregor, or Robert Roy MacGregor. For the next 200 years The Clan Gregor endured this persecution. Men were killed while women and children were sold into slavery in the New World. Finally, in 1774, the Act of Proscription against the clan … Click to read more!

2

Border Reivers DNA Research


A study conducted by researchers at the Institute of Human Genetics at the Center for Life in Newcastle, England discovered that only 50% of males with the last name Robson can be traced back to a recent single ancestor. The research, commissioned to create a new exhibit called “The Robson Encyclopedia,” compared 12 markers from the Y-chromosomes of 100 male volunteer Robsons.
Apparently the Border Reiver clan of the Robsons in the Tyne Valley was notorious in the 1600’s and was made famous in a book called “The Steel Bonnets” by George MacDonald Fraser. According to one site:
“The term Border Reivers describes a number of English and Scottish families who fought a seemingly endless series of bloody confrontations from the 13th Century to … Click to read more!

7

The Biggest Family Reunion Ever Based on Genetic Genealogy?


Yesterday The Jewish Press announced the “Kohen and Levi Conference: A Gathering of the Tribe.” The conference, to be held on July 15-19, 2007, is hosted in Jerusalem by The Center for Kohanim. The Center was founded in 1985 to “promote identity and knowledge among Kohanim the world over, and increase their feelings of awareness and commitment to their heritage as Kohanim.” The conference has a main page, a press release, and a brochure (pdf). According to the press release:

Recent scientific research and DNA testing has proven that today’s descendents of the biblical Kohanim are genetically related. Molecular geneticists have discovered the “Cohen Modal Haplotype” which is a Y- chromosome DNA lineage signature shared by a majority of both Ashkenazi and Sephardi Kohanim. This indicates a direct patrilineal descent of present-day Kohanim from a single ancient ancestor, genetically dated to have lived approximately 3,300 years ago, a time corresponding to the Exodus from Egypt.

Now, the members of this “extended family” are being invited to participate in a ‘family” reunion that will take place in Jerusalem, July 15-19, 2007. These dates coincide with the biblically noted date of the passing of Aharon, the High Priest, on the first day of the Hebrew month of Av.

“This is not only the first family reunion of the Jewish priestly dynasty in nearly 2,000 years, it is an important conference which will inform, inspire and motivate,” stated conference organizer Rabbi Yaakov Kleiman, director of The Center for Kohanim in Jerusalem and author of the book, DNA & Tradition. “The research and information we will share will play an important role in appreciating and maintaining our unique and precious heritage.”

Genetic Genealogy has always been somewhat controversial because it raises issues of social science. For instance, what is race and how is race defined?  How does science define any group of people?  Should genetics be part of that definition? The topic of a “Jewish gene” is no exception, … Click to read more!