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Recreating a Grandmother’s Genome – Part 2

In my last post (see “Recreating a Grandmother’s Genome – Part 1”), I introduced my grandmother Jane, who died when I was just 8 years old. Although I have only a few memories of my grandmother, I have 25% of her DNA. To explore this rich genetic legacy, I’m trying to recreate as much of my grandmother’s genome as possible using the GEDmatch Tier 1 tool called “Lazarus.”

In the last post we also learned about the new Lazarus tool. In today’s post, we’ll choose what kits to use for my grandmother’s Lazarus kit.

Finding DNA Kits for Lazarus

GROUP 1 – DESCENDANTS ONLY

So GROUP 1 must be descendants of the target Lazarus kit. My grandmother has six children, twelve grandchildren, and eleven great-granchildren. Any of these 29 people are candidates for GROUP 1. Of those 29 people, I’ve tested four of the six children and one of the grandchildren (myself). Yeah, I know, I have more testing to do!

... Click to read more!

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Small Matching Segments – Examining Hypotheses

Last week I published “Small Matching Segments – Friend or Foe?” to join in the community’s conversation about the use of “small” segments of DNA, referring to segments 5 cM and smaller (although keep in mind that the term “small,” without a more specific definition, will mean different things to different people).

The question that the community has been struggling with is whether small segments of DNA can be used as genealogical evidence, and if so, how they can be used.

As I wrote in my post, a significant percentage of small segments are false positives, with the number at least 33% and likely much higher. In my examination and in the Durand paper I discuss, a false positive is defined as a small segment that is not shared between a child and at least one of the parents.

... Click to read more!

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Goodbye False Positives! AncestryDNA Updates its Matching Algorithm

AncestryDNAYesterday, when I checked my AncestryDNA account I had 205 pages of matches, or 10,250 matches in the database. Today, thanks to Ancestry’s new matching algorithm, I have 57 pages of matches, or 2,850 matches in the database (a reduction of 72.2%!). I also have DNA Circles, groups of people who MIGHT share a common ancestor (some of whom share DNA with me).

A New Matching Algorithm

I wrote recently about the new algorithm (see “Finding Genetic Cousins – Separating Fact from Fiction“), as did Judy Russell (“When less is more“) and Roberta Estes (“DNA Day With Ancestry“). In essence, AncestryDNA is leveraging information about allele frequencies (“pile-ups”) in which small IBS segments of DNA shared by many, many people are not utilized for matching.

... Click to read more!

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Transfer Raw Data to Family Tree DNA for $39 (Sneak Peek for FREE!)

At the Family Tree DNA 10th Annual International Conference, FTDNA announced that they were reducing the price of autosomal DNA transfers (from the AncestryDNA test or the V3 test from 23andMe) from $69 to $39. Additionally, you could upload your raw data for free and you would receive information about your 20 closest matches in the database. On top of that, if you convinced 4 others to transfer their raw data, you would receive a transfer for free!

It looks like the site went live tonight! The link is (www.familytreedna.com/autosomaltransfer).

Here’s what you see at the intro screen:

AutosomalTransfer

autosomaltransfer1

Once you’ve uploaded, you’ll receive an email with a login and password. You’ll then receive a second email a short time later, after your results have been processed. In the meantime, you’ll see this:

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Finding Genetic Cousins – Separating Fact from Fiction

AncestryDNAShort Summary: Before the end of the year, AncestryDNA plans to update our match lists using a new algorithm that reduces the number of false positive matches. For the first time, matching DNA segments will be characterized as IBS (i.e., a false positive) based on something other than simply segment length.

AncestryDNA Day

Last Monday, October 6th, I and six other members of the genetic genealogy community attended a ‘Bloggers Day’ hosted by AncestryDNA at the San Francisco headquarters of Ancestry.com. Two other members of the group have already written about the event:

While at ‘Bloggers Day’ we discussed many issues including the Y-DNA and mtDNA databases originally scheduled for destruction, upcoming changes to AncestryDNA’s matching algorithm (much more below), and other upcoming changes to the AncestryDNA about which you will hopefully soon hear much more.

... Click to read more!

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A Conversation About Genetic Genealogy

Earlier this week, I had the opportunity to speak with Michael Leclerc at Mocavo about DNA, our genealogical beginnings, and so much more. Michael recorded our conversation, and it’s now available as this week’s Mocavo Fireside Chat!

If you’re curious about Y-DNA, mtDNA, or autosomal DNA, or have questions about DNA in general, I think you’ll enjoy this Fireside Chat. And be sure to check out the previous chats, it’s a lineup full of great guests!

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DNAGedcom Announces New Tools For Genetic Analysis

DNAGedcomThe DNAGedcom team (lead by Rob Warthen, Diane Harman-Hoog and Karin Corbeil) would like to announce the following new items to the DNAGedcom system.

Product: Jworks – Autosomal Grouping Tool
Developer: Juan “Jay” Pizarro
Release Date: May 12, 2014

Download or Locationhttp://dnagedcom.com/Auto/JWorks.aspx

What It Does: This Excel based tool sorts and groups your chromosome browser results from FTDNA into overlapping DNA sets and assigns the ICW status within the set. By following the paper “Combining Results from All Tests” , the tool can also be used to organize the output from all three testing services. You must have Excel to use this. A Mac Version is also available.

Directions: Full directions are found on a link with in the product interface on dnagedcom.com

... Click to read more!

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The 2014 International Genetic Genealogy Conference

I4GG

I know I say this every year, but 2014 is shaping up to be the year of Genetic Genealogy. There are many incredible opportunities this year for anyone interested in genetic genealogy to learn more and interact with others.

For example, just last month RootsTech 2014 featured numerous DNA sessions. This coming June, there will be an entire day of DNA at the 2014 SCGS Jamboree, where I and many other speakers will cover numerous topics related to DNA (see my coverage here and here). Among my presentations at Jamboree will be a completely new lecture that I’m really excited about – “DNA and the Genealogical Proof Standard,” which will be the first presentation completely devoted to the topic, and which I hope will spur some important conversation!

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The AncestryDNA Witch Hunt

A word of advice: beware anyone who tells you to avoid AncestryDNA.AncestryDNA1

Many genetic genealogists, myself included, have had incredible success using AncestryDNA’s autosomal DNA test.  Personally, several of my own major DNA discoveries have occurred though the service.  Unfortunately, it has become popular among some genetic genealogists to deride AncestryDNA’s autosomal DNA test, and some recommend avoiding the service altogether.

While AncestryDNA certainly does have limitations, avoiding the service is missing out on a major opportunity and one of the largest autosomal DNA databases in the world.  This is especially true for adoptees; anyone that tells an adoptee not to test with AncestryDNA (or not to test with any one of the three major testing companies) should not be assisting adoptees.

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New Updates From Family Tree DNA

Following a trend inspired by discussions at the recent Conference for Family Tree DNA Group Administrators, Family Tree DNA has released a new set of updates.  This week’s update includes the ability to change the location for your most distant known maternal or paternal ancestors, and the ability to determine which of your Family Finder matches actually match each other.  Although this functionality was previously available, it was cumbersome and was not accompanied by any visualization.

From Family Tree DNA:

Weekly Information Technology/Engineering Update (10 Dec 2013)

Matches Maps Locations Clear Button

Some users have requested the ability to clear their stored map coordinates for their most distant known maternal or paternal ancestors. We have added a Remove Location button to Step 3 of the Update Most Distant Ancestor’s Location wizard.

... Click to read more!