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Genetic Genealogy in Somerset, Pennsylvania

The Daily American Newspaper in Somerset, Pennsylvania, recently highlighted a family surname study being conducted through a local forensics company.  The Eustace/Eustis/Eustice surname Y Chromosome DNA study began in July 2006 and according to the news article the project has tested 80 men in eight countries, a remarkable number.

Ron Eustice, one of the leaders of the study and editor of the Eustice Families Post newsletter emphasizes the importance of DNA to his genealogical research:

“Most family historians have spent countless hours poring over genealogical records, trying to connect the dots.  DNA testing is rapidly establishing itself as the newest and perhaps most reliable tool in the field of family history research. I believe that including DNA evidence is an essential part of family history research.”

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The Monday Morning DNA Testing Company Review – Argus Biosciences

header11.jpgArgus BioSciences, located in Belmont, California, is an up-and-coming company offering DNA sequencing for the study of genetic genealogy.Founded in 2003 by Dr. David Whyte, the company offers mtDNA sequencing and haplotype determination.

Although Argus is currently (as of March 2007) offering only mtDNA testing, all products are being offered at a greatly reduced rate.Sequencing of the hypervariable region (which includes HVR1-3) is offered for only $125.00 (regularly $149).You can compare this price to those offered by other companies in my DNA testing company comparison chart.Additionally, Argus is offering complete sequencing of the entire mitochondrial genome (16, 569 bases) for $345 (regularly $695).The company will also accept four monthly payments of $95 to pay for a full sequencing (to inquire, contact Argus at info@argusbio.com).Currently only one other company (Family Tree DNA) offers complete mtDNA sequencing as a regular product.

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Genetic Testing Companies

The last time I counted there are at least 21 unique companies offering DNA testing for genealogical purposes, either Y-chromosome, mtDNA, or autosomal testing (see the Sidebar to the right for a listing).  To get a clearer picture of what each company offers I created a master list of every company and the services they offer.  See here.

While compiling the list I also gathered information about the markers that each Y-chromosome test analyzed.  See here.  There are of course the standard markers offered by most companies as well as the markers offered by only a single company.  What company have you been tested by?

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The Monday Morning DNA Testing Company Review – AncestryByDNA

migrationmap_big.jpgAncestryByDNA is a popular genetic test developed by DNAPrint Genomics, Inc.The company offers a variety of genetic testing, including Y-chromosome and mtDNA ancestry.They are most well-known, however, for their two admixture tests.Admixture tests examine SNPs, or single nucleotide polymorphisms, in the 22 autosomal chromosomes in each of our cells.Although every human’s DNA is 99.9% identical, the 0.1% differences make each one of us unique.Researchers have noticed that people in a particular region often have a mutation in common, one that people in most or all other regions of the world do not have.These usually harmless mutations, called SNPs, are believed to have bio-geographic properties – people endogenous to certain regions of the world have different versions of the SNPs.A person who submits his DNA for analysis could have SNPs which reveal genetic contributions from a wide variety of regions.

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Who Crossed the Bering Land Bridge?

dna2.jpgHow many founding Asian groups braved their way across the Bering land bridge during those frigid Pleistocene ice ages?Was it a single wave of people who later developed into the three distinct linguistic and cultural groups that populated the Americas, or were there multiple waves of people each with their own language and culture? Or was it some mix of the two?The issue has been and continues to be a topic of debate.

Linguistic studies of the Na-dene, Aleut-Eskimo, and Amerind language groups suggested that there were three waves across the land bridge, one for each language group.Recent genetic research, however, has suggested that there was only a single wave of founding groups into the Americas. (Read a free online review here).

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DNA Testing Jumps During Black History Month

 

With the arrival of Black History Month and following on the heels of PBS’s popular series ‘African American Lives’, increasing numbers of African Americans are deciding to explore the world of DNA testing and genetic genealogy.As a result many newspapers and magazines are taking the opportunity to introduce their readers to this increasingly popular avenue of genealogical research.

The Rocky Mountain News in Denver, Colorado is currently three articles into a six-part series examining the role and effect of genetic genealogy in African American research [Thanks to Genealogy Reviews Online]:

Saturday, 17 February 2007 (Two articles, here and here).
Monday, 19 February 2007
Tuesday, 20 February 2007
Wednesday, 21 February 2007
Thursday, 22 February 2007
Friday, 23 February 2007

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Scottish DNA Database Being Created at Glasgow Caledonian University

Genealogists interested in researching their Scottish roots will soon have a new resource thanks to a new genealogy center created by the Glasgow Caledonian University in Scotland.  The center will join together traditional genealogical research with recent advances in genetic genealogy to help individuals verify their Scottish roots with DNA testing.  According to the Scottish Tourist Board at VisitScotland.com, more than 50 million people throughout the world can claim Scottish ancestry.

This testing will be done by mouth swab and will be conducted in a new forensics lab built at the University.  The center will use both Y-chromosome and mtDNA results to build their database.  Researchers at the University hope that the center will eventually be able to build a genetic map of the clans of Scotland by looking for markers that are specific for each particular clan.  The test should cost around GBP60 ($120USD), and a number of people have already expressed an interest in the test.

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The Monday Morning DNA Testing Company Review – African Ancestry

African Ancestry has had a very good year.  The popular PBS series ‘African American Lives’, which analyzed the African roots of nine famous figures (such as Oprah, Quincy Jones, Whoopi Goldberg, Chris Tucker, and Dr. Sara Lawrence-Lightfoot), used the African Lineage Database developed by the Scientific Director of African Ancestry, Dr. Rick Kittles.  This publicity has resulted in African Ancestry being featured in a wide array of newspaper and magazine articles around the world.

African Ancestry offers two types of DNA analysis, the Matriclan test and the Patriclan test.  The Matriclan test sequences a portion of an individual’s mtDNA to determine whether the ancestry of that lineage is African, European, or other ethnic group.  If the ancestry is African the company will compare the sequence to the African Linage Database.  This exclusive database is African Ancestry’s strongest selling point.  It contains lineages sampled from over 30 countries and 160 ethnic groups in Africa.  The maternal lineage database, for example, contains almost 14,000 samples.

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DNA Analysis of Ancient Human Neolithic Remains in Northeastern Siberia

Researchers have analyzed the (abstract here) HVR1 (hypervariable region 1) of the mtDNA control region belonging to an ancient female skeleton.  The skeleton, approximately 3,600 years old, was discovered in 1980 in a frozen Neolithic grave in northeastern Siberia.

Sequencing of a 377-base pair fragment (16015-16391) revealed three mutations; C16223T, T16298C, and C16327T.  These mutations are characteristic of haplogroup C in Siberian and Asian populations.

An Identifying Allele Found Among All Native American populations

A recent study by has characterized an allele that is present in all Native American populations tested.The allele, 9RA (9 repeat-allele) is a 9 tetranucleotide repeat allele composed of 275 bp at autosomal (meaning non-sex chromosome) microsatellite locus D9S1120 (on chromosome 9).Microsatellites are small DNA repeats that are typically neutral and are often used as molecular markers for population studies.According to the report, 9RA was found at an average percentage of roughly 30% among all the populations.

Although 9RA was found among Chukchi and the Koryaks of Western Beringia (on the eastern edge of Siberia), the allele was not identified in the large number of Asian populations tested (perhaps because this is a mutation that arose in populations as they approached the land bridge or because the sample size was not big enough to detect it).

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