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What Else Can I Do With My DNA Test Results?

DNAIn addition to the information you received from 23andMe, Family Tree DNA, or AncestryDNA about your ancestry, there is a wealth of additional information still within in your DNA.  Below (in alphabetical order) are some of the most popular and well-known tools for wringing every last bit of information out of your raw data, and maximizing the cost of your DNA test.  Please note that I have not used or verified all of these apps; always use caution when providing information to an unknown recipient.

Apps, Extensions, Programs, and Websites:

  • 23++ (http://23pp.david-web.co.uk/about/) (FREE) – An extension for the Google Chrome web browser that adds additional functionality to the 23andMe website. The extension especially adds a number of features to Relative Finder.
  • 529andYou (http://goo.gl/FQSiwW) (FREE) – An extension for the Google Chrome web browser that works with 23andMe’s Family Inheritance: Advanced tool (found under Ancestry Labs or, in the new beta website design, under My Results, Ancestry Tools) to collect information about DNA matches.  The information, which includes shared segment data, is stored in a local database on your computer.
  • David Pike’s Utilities (http://www.math.mun.ca/~dapike/FF23utils) (FREE) – A comprehesive suite of tools for analyzing raw data, including searching for Runs of Homozygosity (ROHs), searching for shared DNA in two files, and several advanced phasing tools.
  • DNAGedcom (http://www.dnagedcom.com) (FREE) – A suite of tools for 23andMe and Family Tree DNA customers.  Users can download their matches, shared segments, and other data into a handy spreadsheet for further analysis.
  • DNAMatch4iPad (http://www.dnamatch4ipad.com) ($) – A app for the iPad that is an “alternative to the use of conventional spreadsheets for the processing of autosomal DNA data.” Users download their match data from one of the testing companies in the form of a .CSV file and upload it to DNAMatch4iPad.
  • GEDmatch (http://gedmatch.com/) (FREE) – A powerful suite of tools for 23andMe, AncestryDNA, and Family Tree DNA raw data.  Users can compare their DNA to everyone else in the database or to a specific individual in the database, or perform numerous admixture analyses, phase their DNA, and much more.
  • Genes & Us (http://www.genesand.us)  (FREE) – A website for 23andMe users to “combine their genomes in order to better understand what disease risks most affect their family.”  For example, a mother and father can link their 23andMe accounts to the site and determine the possible combinations for their children’s DNA.  Appears to work with 23andMe’s new API offering.
  • Genetic Genealogy Tools (http://www.y-str.org) (FREE) – An impressive and ever-growing list of advanced tools for analyzing raw data, including an X-DNA Relationship Path Finder, Ancestral Cousin Marriages, Autosomal Segment Analyzer, a DNA Cleaner, a SNP Extractor, My-Health, and many more!  A terrific resource from Felix Jeyareuben Chandrakumar, an Australian software professional.
  • Genetic Genie (http://geneticgenie.org/) (FREE) – A tool that analyzes your 23andMe results to perform a methylation gene analysis (“Methylation Analysis”).  The site also provides a tool for a “Detox Profile” which looks for defects in the Cytochrome P450 detox enzymes.  The site uses the 23andme API, so users can link their 23andMe account to the service.
  • Genetrainer (https://www.genetrainer.com/) ($) – Users of 23andMe and Family Tree DNA can link their results to the Genetrainer service, which will then provide you with training plans and exercises personalized to the user.
  • HIR Search (http://hirs.snpology.com) (FREE) – Once your raw data is entered in the database, you can find HIRs (half-identical regions) that you share with others in the database.
  • Imputation Tools (http://mathgen.stats.ox.ac.uk/impute/impute_v2.html) and (http://faculty.washington.edu/browning/beagle/b4.html) (FREE) – Sometimes you find a SNP in the literature that isn’t tested by any of the big testing companies.  Imputation allows you to determine the most probable genotype for that SNP based on the surrounding SNPs and a database of known sequencing results (such as the 1000 Genomes data).  IMPUTE2, for example, is a computer program for phasing observed genotypes and imputing missing genotypes.  See more about IMPUTE2 here, including a link to a script to convert your 23andMe raw data to a useable form.  BEAGLE4 is similarly performs genotype calling, genotype phasing, imputation of ungenotyped markers, and identity-by-descent segment detection.  Learn how to use BEAGLE4 here.
  • Interpretome (http://esquilax.stanford.edu/) (FREE) – A collection of tools for analyzing 23andMe raw data using only a web browser (i.e., raw data is not uploaded).  The tools include an admixture analysis, health information, and a Neanderthal calculator.
  • Minor Allele Program (http://www.ianlogan.co.uk/23andme/23andMe_index2.htm) (FREE) – A tool to identify rare SNPs in your 23andMe or Family Tree DNA raw data.  My own results are available here.
  • mtDNA Haplogroup Analysis (http://dna.jameslick.com/mthap/) (FREE) – A terrific tool for predicting your maternal haplogroup using a variety of formats, including 23andMe raw data.
  • NAT2PRED (http://nat2pred.rit.albany.edu) (FREE) – a tool for inferring human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype.  In other words, a tool for predicting the function of your NAT2 enzyme (either slow, rapid, or intermediate) based on your DNA.  The NAT2 enzyme is involved in activating and deactivating arylamine and hydrazine drugs and carcinogens, among other things.
  • Promethease (https://promethease.com/ondemand) ($5) – Analyze your 23andMe, Family Tree DNA, or AncestryDNA raw data and build a report based on SNPedia. Reports contain information about health and ancestry as well as several other new options.  A sample report is here.
  • Segment Mapper (http://kittymunson.com/dna/SegmentMapper.php) (FREE) – A tool to show specific DNA segments in a graphic chromosome-style chart.  This is a clever and powerful “mapping” tool.  Learn more about the tool here.
  • SNPTips (http://snptips.5amsolutions.com/) (FREE) – A Firefox browser extension that allows 23andMe customers to access their SNP genotype information without logging into their 23andMe account or leave the webpage they are browsing.  Users can simply hover their mouse cursor over a SNP RSID on a webpage and, if that was tested by 23andMe, the SNPTips extension will provide a popup with the user’s genotype and some relevant links.
  • SPA (http://genetics.cs.ucla.edu/spa/index.html) (FREE) – Spatial Ancestry analysis (SPA) is a method for predicting ancestry or where an individual is from using the individual’s DNA. 23andMe users can download the software and analyze their results with this admixture tool.
  • The 23andMe Gene App at Livewello (https://livewello.com/23andme) ($19.95) – a Variance Report Software analyzes 23andMe Raw Data are reports on 300 SNPs for things like “Methylation Detox, Immune Factors, IgE, IgG disorders and much more.”  Livewello is a Social Health Management Platform with customized App.

Did I miss anything?  Do you have any suggestions or comments regarding the programs listed above? Feel free to let me know in the comments below!

Blaine Bettinger

Intellectual property attorney, genealogist, and author of The Genetic Genealogist since 2007

37 Comments

  1. All I can say Blaine is “thanks.” I’m aware of some of these and make use of them but boy do I have work to do today.

  2. After reading this I am overwhelmed. I had a DNA done with Ancestry and am waiting on results from 23 and me for my youngest adult son and myself.

  3. Pat – don’t be overwhelmed! These tools and sites are all optional, and you don’t need to use them to gain plenty of information about your ancestry from your results.

  4. http://scistore.cambridgesoft.com/ScistoreProductPage.aspx?ItemID=7343

    This is professional microarray raw data analysis software program, so be warned, only those with REALLY deep pockets will be able to afford it. However, the page does have a link to free trial software. I have not downloaded the free trial, because it requires registration, and “Orginization” is a required field. This company might choose to exclude individual users. Should anyone, acting as an individual and not as an orgizational representative, sucessfully download and use this trial, please report your impressions. I have looked at the company website, and read their brochures. This software promises one click, ease of use, and the report presentation and variety are truely amazing. A good read.

    • http://scistore.cambridgesoft.com/ScistoreDiscountPricing.aspx

      The above link will take you to a page displaying the products that are on sale, during the current month. The reason I did not try to DL the trial is that my own raw data is not yet available. With the price as high as it is, I am pretty sure that the trial will be very time-limited, and I don’t want to risk wasting a one-shot trial, until I can analyze my own data. I assume that the trial will also have some abilities disabled (like actually printing results), but as long as the analysis functions work and the results are displayed, a screenshot will be just fine.

  5. Hello, this weekend is pleasant in favor of me, because this occasion i am reading this impressive educational article here at my home.

  6. WOW thank you! I want to purchase a 23andMe DNA test soon, and am trying to learn as much as possible about how and where to aim the raw data so I can use it to interpret toward figuring out many of my own health issues. I have met w such drama from many people who insist this is not possible and that 23+Me must have been selling erroneous information all this time. Isn’t the DNA data they sell the precise same data that any other company or lab sell me? I do get that they are being prohibited from offering too much ‘interpretation’ as a selling tactic, but their methods/tech/product are still scientifically real and valid, correct?
    …and thank you again for this clear article, I found this through a Search on DuckDuckGo
    ~ EF

  7. I’m in search for tools like promethease to look on pharmacogenomics. I have my snp’s and full genome. Ca

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  11. I want to use my raw data to find out everything I possibly can about medical history, disease markers, etc. What is the best company (app, website, software, whatever) out there for this? Thanks..

  12. APP UPDATE!!!
    Livewello’s web based Application will now accept Raw Data from almost any personal genomics company in the world.
    As long as a Gene is in your Raw Data, with the Minor Allele and rsID, Livewello will generate your Gene Report with it for you. Here are some of its New Features:

    1) A Standard Gene Variance Report:
    Video: https://vimeo.com/97313986
    A Standard Sample Gene Variance Report: http://bit.ly/1wxbZUO

    2) A Gene Library: https://livewello.com/snps/library
    Contains hundreds of Gene compilations you can use to generate a report for yourself. EXAMPLES:
    MTHFR GENE REPORT: https://livewello.com/snps/library?action=preview&index=393575&for=demo

    METHYLATION REPORT: https://livewello.com/snps/library?action=preview&index=899200&for=demo

    3) A Health Conditions Tool to help you find and generate your results on Genes associated with certain Health Conditions based on research studies: https://livewello.com/gwas

    EXAMPLES: HYPOTHYROIDISM GENES: https://livewello.com/snps/library?action=preview&index=335986&for=demo

    ULCERATIVE COLITIS GENES: https://livewello.com/snps/library?action=preview&index=186332&for=martin.dawson.606
    How-To Video: http://vimeo.com/96957497

    4) A SNP Sandbox Tool used to create Gene reports based on a Gene Name or any combination of SNPs: https://livewello.com/snps/sandbox
    How -To Video for 23andMe users: http://vimeo.com/103512972
    How -To Video for other Personal Genomics Co. users: http://bit.ly/1ofh3tC
    SNP Sandbox EXAMPLES:

    YASKO NUTRIGENOMICS GENES: https://livewello.com/snps/library?action=preview&index=55692&for=johnadams

    PARKINSON’S DISEASE: https://livewello.com/snps/library?action=preview&index=41870&for=demo

    LACTOSE INTOLERANCE: https://livewello.com/snps/library?action=preview&index=257796&for=florence

    AUTISM SPECTRUM DISORDER, ADHD, BIPOLAR, MAJOR DEPRESSIVE DISORDER, & SCHIZOPHRENIA GENES: https://livewello.com/snps/library?action=preview&index=379628&for=johnadams

    5) A Personal Health Management Tool that helps you manage your
    ~Health issues: https://livewello.com/health/dx
    ~Medications & Supplements: https://livewello.com/health/rx
    Video Demo: https://vimeo.com/103746466

    6) Data Apps for keeping track your other Lab test results: https://livewello.com/data-apps

    7) Comprehensive learning and research Resources like Medline, GHR, Google Scholar, dbSNP, Ensembl, Wiki Genes, PubMed, SNPedia and Uniprot. , Wiki Genes, PubMed, SNPedia and Uniprot.

    Questions? Go to https://livewello.com/contact-us

  13. Go to KnowYourGenetics.com and enter your DNA Test results for a FREE personalized supplementation report. Use the “Work Book” as your step by step guide to help your throughout the next phase of the processes. There are other great FREE resources linked on the side of the page.

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