The Genetic Genealogist

Adding DNA to the Genealogist's Toolbox

Archive for October, 2007


Links From The Genetic Genealogist – October 31, 2007

In order to clean out posts I’ve been saving in Google Reader (does anyone else keep posts in Reader until you’ve blogged about them?), I decided to have a potpourri day. The following are links to interesting articles around the blogosphere. And Happy Halloween!

Pedro at Public Rambling has The Fortune Cookie Genome, a ‘science fiction’ post about picking up the results of his whole genome scan from his genetic advisor. Of course, it’s only science ‘fiction’ until it’s science ‘reality’!

The Women’s Bioethic Project has an article about DNA Testing Without Consent, which asks whether there should be a ‘reverse’ statute of limitations for testing DNA from famous dead people. The article was written in response to a recent story in Parade. I talked about this briefly back in August (see “DNA From the Dead“), and I’m working on a post about “Discarded DNA and the Constitution”, so stick around. HT: Eye on DNA.

Tim at Genealogy Reviews Online continues his review of DNA Ancestry with DNA Ancestry Review Part 2. In this installment, Tim describes the DNA collection process.

At The Tree of Life, Jonathan Eisen presents the Overselling Genomics award to Newsweek as a result of their “10 Hottest Nerds” story. Personally, I think any story that brings science to the masses in an connectable way is beneficial, but I agree that the lack of women on the list was a huge oversight.

At genomeboy.com, Misha Angrist dissects the recent Portfolio piece about personal genomics companies such as 23andMe and Navigenics. He also highlights that familiar $12.5 billion “potential market” quote. I wish I knew who and how that number has come from.

And finally, Alan Boyle at Cosmic Log writes about The Secrets in Your Genome, which is about the International HapMap Consortium’s latest release:

“Today’s map of genetic variations, also known as a haplotype map (hence the word HapMap), follows up on the international consortium’s first map, issued in 2005. The first map analyzed about 1 million variants in the human genome. This second map charts more than 3.1 million of the variants – also known as single-nucleotide polymorphisms, or SNPs”

Navigenics and 23andMe From VentureBeat: Life Sciences

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David Hamilton at VentureBeat: Life Sciences recently wrote about the potential business plans of two popular genomic companies – Navigenics and 23andMe. It appears that the post was motivated by the recent article in Portfolio. David writes:

“Over the last few months, startups like 23andMe and Navigenics have attracted a fair bit of attention for promising to let ordinary people search through their own genomes to better understand their disease risk, genealogy and ancestry. One of the first major efforts to figure them out, however — courtesy of the November issue of Portfolio — left me with the distinct impression that these companies may not actually be anywhere near as revolutionary as they seem.”

There’s some discussion in the comment section, and David presents a number of links to the many previous articles he’s written about 23andMe and Navigenics.

Should We All Be Testing Our DNA?

That’s the title of an article at BBC News yesterday. The article’s header states that:

“More and more people in the UK are following America’s lead in spending hundreds of pounds on private genetic tests.”

The article is about genetic testing for health concerns, not for genealogical purposes. Although the article is very short, the author does manage to highlight a few of the potential benefits and downfalls of genetic testing.

A Contest From DNA Heritage

DNA Heritage is hosting a video contest for people who have undergone DNA testing for ancestral purposes. Following are the details of the contest:

Dear Customer,Thank you for all of your suggestions for improving the website which we have put into motion. Among them is flexible DNA storage, which we shall implement at the end of this month (we’ll let you know when).Spotted the video link on our home page? We wanted to hear about your own experience.Have a story to tell?

Want to tell people why you took a DNA test or what it told you about you and your family? How has it helped your research? How did you do it and what did you get out of it?

Tell us by video and we’ll give you 50% off your next test, be it for you, a friend or some distant cousin in another part of the world. Not a bad Xmas present for a few minutes work…

If we think it’s the best one we’ll give you three free tests.

Two runner-ups will get a free test each.

And you get to choose the test be it a Surname DNA, Paternal Roots or Maternal Roots test.

The Rules.

  • Have fun with it
  • Much like international figure skating, points are awarded for transitions, performance/execution, choreography/composition and interpretation
  • Must be somewhere between 1 and 5 minutes long
  • Must mention us by name
  • You can name-drop Ybase too
  • Let us upload it our site and to sites like YouTube etc.
  • Email it to us before December 1st 2007 we’ll judge it right after that in time for Xmas
  • The tests need to be used by the end of February 2008
  • Accepted in WMV, AVI, MOV, MPEG and MP4 formats – pretty much anything

Best of luck to all you budding Cecil B. DeMilles!

Sincerely,
Alastair Greenshields
Principal
DNA Heritage

10 DNA Testing Myths Busted

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1. Genetic genealogy is only for hardcore genealogists.

Wrong! If you’ve ever wondered about the origins of your DNA, or about your direct paternal or maternal ancestral line, then genetic genealogy might be an interesting way to learn more. Although DNA testing of a single line, such as through an mtDNA test, will only examine one ancestor out of 1024 potential ancestors at 10 generations ago, this is a 100% improvement over 0 ancestors out of 1024. If you add your father’s Y-DNA, this is a 200% improvement. Now add your mother’s mtDNA, and so on. However, with this in mind, please note the next myth:

2. I’m going to send in my DNA sample and get back my entire family tree.

Sorry. DNA alone cannot tell a person who their great-grandmother was, or what Italian village their great-great grandfather came from. Genetic genealogy can be an informative and exciting addition to traditional research, and can sometimes be used to answer specific genealogical mysteries.

3. I would like to try genetic genealogy, but I’m terrified of needles.

Good news! Genetic genealogy firms don’t use blood samples to collect cells for DNA testing. Instead, these companies send swabs or other means to gently obtain cells from the cheek and saliva.

4. I would like to test my ancestor’s DNA, but they died years ago.

You don’t always need your ancestor’s DNA to get useful information from a genetic genealogy test. If you are male, you contain the Y-chromosome (Y-DNA) that was given to you by your father, who received it from his father, and so on. Both males and females have mitochondrial DNA (mtDNA), which was passed on to them by their mother, who received it from her mother, and so on. Everyone of us contains DNA (Y-DNA and/or mtDNA) from our ancestors that can be studied by genetic genealogy.

5. I want to test my mother’s father’s Y-DNA, but since he didn’t pass on his Y-chromosome to my mother, I’m out of luck.

Wrong! There is a very good chance that there is another source of that same Y-DNA. For instance, does your mother have a brother (your uncle) who inherited the Y-DNA from his father? Or does your mother’s father have a brother (your great-uncle) who would be willing to submit DNA for the test? Sometimes there might not be an obvious source of “lost” Y-DNA, or no one in the family is willing to take a DNA test. The secret to solving this problem is to do what every good genealogist does – use traditional genealogical research (paper records, census information, etc) to “trace the DNA”. Follow the line back while tracing descendants in order to find someone who is interested in learning more about their Y-DNA. This applies to finding a source of mtDNA as well.

6. Only men can submit DNA for genetic genealogy tests, since women do not have the Y-chromosome.

Wrong! Most genetic genealogy testing companies also offer mtDNA testing. Both men and women have mtDNA in their cells and can submit that DNA for testing. In addition, women can test their father’s, brother’s, or some other male relative’s Y-DNA to learn more about their paternal ancestral line, even though they did not inherit the Y-chromosome.

7. My genetic genealogy test will also reveal my propensity for diseases associated with the Y-chromosome and mtDNA.

Wrong, thank goodness. Most of the information obtained by genetic genealogy tests has no known medical relevancy, and these firms are not actively looking for medical information. It is important to note, however, that some medical information (such as infertility detected by DYS464 testing or other diseases detectable by a full mtDNA sequence) might inadvertently be revealed by a genetic genealogy test.

8. I don’t like the thought of a company having my DNA on file or my losing control over my DNA sample.

This is, of course, an understandable concern. However, most testing firms give a client two options: the DNA is either immediately destroyed once the tests are run, or it is securely stored for future testing. If the DNA is stored, the firm will typically destroy the DNA upon request. If the long-term storage of DNA is a concern, be sure to research the company’s policy before sending in a sample.

9. If my test reveals Native American ancestry, I plan to join a particular Native American affiliation group.

Although genetic genealogy can potentially reveal Native American ancestry (for instance, my mtDNA belongs to the Native American haplogroup A2), it is incredibly unlikely that this information will be sufficient to positively identify the specific source of the lineage (such as a tribe) or allow membership in a particular Native American affiliation.

10. My DNA is so boring that genetic genealogy would be a waste of time and money.

Very wrong! A person’s DNA is a very special possession – although everyone has DNA, everyone’s DNA is different (okay, except identical twins – if your identical twin has been tested, you should think twice about buying the same test!). As humans settled the world, Y-DNA and mtDNA spread and mixed randomly. As a result, it is impossible to guess with 100% assurance that a person’s Y-DNA or mtDNA belongs to a particular haplogroup (a related family of DNA sequences) without DNA testing.

BONUS MYTH: My genetic genealogy test says that my mtDNA belongs to Haplogroup A2. Juanita the Ice Maiden, a frozen mummy discovered in the Andes Mountains in Peru also has Haplogroup A2 mtDNA. Therefore, she must be my ancestor!

Unfortunately, although genetic genealogy can reveal that a person is RELATED to an ancient DNA source, it cannot prove that a person is a DESCENDANT of an ancient DNA source. For instance, perhaps you are descended from Juanita’s sister, or her 5th cousin. Thus, although Juanita might be your great-great-great-great…great-grandmother, she might instead be your great-great-great-great…great-aunt. And since Juanita died when she was just 12 to 14, it is unlikely she has any descendants.

If you understand the risks associated with genetic genealogy (such as the detection of non-paternal events and other risks) and are ready and willing to embrace the results to learn more about your genetic ancestry, then genetic genealogy might be for you. I recommend that you read archived posts here at The Genetic Genealogist, and do some online research through one of the many companies that offer genetic genealogy testing.

Genetic Genealogy in Newsweek and The Courier-Journal (Kentucky)

Last week there were a couple of other articles in the news about genetic genealogy:

1. Newsweek.com – “Shaking the Family Tree with Recreational Genetics.” The article is largely in response to last week’s article in Science (see my previous coverage). There are a number of interesting comments following the Newsweek article – I would recommend browsing through them if you have the time.

2. The Courier-Journal – “DNA Discovery.” The article is mostly about Oxford Ancestors.

Sorenson Genomic’s GeneTree Launches

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As I mentioned earlier today, GeneTree has been redesigned, and actually launched this morning. There is a FAQ page, and a new blog. There’s also an extensive Press Room, with logos and screen shots – one of the most impressive I’ve ever seen.

So what is GeneTree? According to the FAQ:

“GeneTree is a family history sharing site created to help people everywhere understand how their personal stories belong within the framework of the greater human genetic story – by discovering their genetic heritage and identity, connecting and collaborating with living relatives, and sharing meaningful information and perspective through personal stories, photos, video and documents.”

I’m sure there will be a lot of media coverage today and over the course of the week, but here is an article at Computerworld. Following is the official press release:

Sorenson Companies Launch GeneTree, a Unique Genetic-Genealogy Social Networking Web Site

‘You Belong Here’ Is Motto of New Web Site that Provides Unrivaled Tools and Resources for Millions of People Who Are Researching and Sharing Their Genealogies Online. New Type of Family History Networking Site Includes DNA Profiles and World’s Largest Genetic-Genealogy Database, Along with Interactive Family Trees, Video-, Photo-, Audio-Sharing, and More.

SALT LAKE CITY (Oct. 23, 2007)—The Sorenson family of companies, an innovative group of enterprises founded by biotech billionaire James LeVoy Sorenson and son James Lee Sorenson, today announced the launch of GeneTree, a new type of family history networking Web site that empowers users with tools and resources to unlock the extensive ancestral information contained within their DNA. GeneTree (GeneTree.com) will allow millions of people to discover their deep family history connections and share meaningful family information and experiences with the worldwide Internet community.

Traditional family history Web sites are already plentiful, and genealogy research is often cited as the second most-popular use of the Internet. But GeneTree is unique because it integrates genetic genealogy with innovative digital media software. The result is a suite of powerful tools to discover and document family history, helping individuals answer the age-old question, “Who am I?”

GeneTree taps into the expertise of several Sorenson enterprises in the forefront of the technologies this new category of Web site links together. Sorenson Media developed the world’s leading digital video compression and encoding software that has been installed on more than 1.2 billion computers. The Sorenson Molecular Genealogy Foundation (SMGF), a non-profit research organization, operates the world’s largest repository of correlated genetic and genealogy information. GeneTree will tie into the SMGF database that currently contains information on more than 6 million ancestors through linked genetic and pedigree data from approximately 90 percent of the world’s countries. Sorenson Genomics, which pioneered Web-based consumer genetic testing, will perform the DNA analysis.

On GeneTree, users can connect with family and friends and preserve their family histories using rich media and social networking technologies. Participants collaborate on assembling detailed family histories with powerful, easy-to-use software for building family trees and by sharing digital media and memories. Users can choose to have their DNA tested and then map those results with the Web site’s worldwide genetic genealogy collection and thereby discover portions of their deep ancestral histories that predate written records. Those who elect to have genetic analysis done may choose from several types of mitochondrial DNA tests ranging in price from $99-$149.

“We are saying ‘You belong here’ to the millions of people in the multi-generational Internet community who are interested in exploring and collaborating on their personal and family histories,” said James Lee Sorenson, GeneTree CEO. “GeneTree provides a fun and compelling way to interact with friends and extended family while leaving the priceless legacy of a richly documented family history. The combination of powerful genetic genealogy resources and easy-to-use digital media sharing tools will make this Web site an important part of people’s online lives. In addition, GeneTree will expand the concept of family for each new user who joins.”

The relatedness testing services provided by the division of Sorenson Genomics formerly named GeneTree will now be offered through Identigene (www.identigene.com), which was recently acquired by Sorenson Genomics.

About GeneTree

GeneTree (www.genetree.com) is a DNA-enabled family history-sharing Web site designed to help people understand where their personal histories belong within the greater human genetic story. GeneTree creates opportunities for unlocking human genetic heritage, discovering ancestors, connecting and collaborating with living relatives, and sharing rich media to help discover, document and preserve family histories. GeneTree was developed by the Sorenson family of companies and draws on the expertise of the Sorenson Molecular Genealogy Foundation, a nonprofit organization that developed the world’s foremost collection of genetic-genealogy information; Sorenson Media, which created of the world’s leading digital video compression software; and Sorenson Genomics, which pioneered Internet-based consumer DNA testing.

Roots – Chris and Alex Haley’s DNA, and the Launch of JeanTree (GeneTree.com)

At the 2007 Federation of Genealogical Societies Conference in August, Alex Haley, the nephew of the Chris Haley – the author of “Roots”, joined the many people who have tested their DNA for ancestral information.  It turns out that his Y-DNA is of European origin.

There’s a post at Megan’s Roots World, a news report at KUTV.com, and the video of Alex swabbing his cheeks for DNA from Roots Television:

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The article at KUTV also contains what MUST be a mistake:

“Next week, The Sorenson Cos. plans to roll out a separate DNA-based Web site called jeantree.com. Chief Executive James L. Sorenson declined to discuss details Tuesday, although it will rely on a larger DNA database.”

Either Sorenson is planning to sell denim-related products, or the journalist misunderstood “Genetree.com”. Stay tuned for further details about the re-launch of this site.

The Genetic Genealogy Community Responds to Last Week’s Article in Science

 

Last week I provided an analysis of the article in Science, “The Science and Business of Genetic Ancestry Testing“, which examined the benefits and pitfalls of genetic genealogy.

There’s been considerable discussion of the article and the author’s conclusions at the Genealogy-DNA mailing list. One of the most interesting posts was by Kim Tallbear, a long-time member of the list and co-author of the Science article. The post, “Response to Genetic Genealogists From Authors of Oct. 19th Science Article“, is important reading for anyone who is following the development of this story. The following is a quote from Dr. Tallbear’s post:

“We orginally had language in the article that noted the expertise of genetic genealogists such as some of you on this list. (My interactions on this listserv taught me well that there is a good deal of expertise here.) But with space constraints the editors cut that language.)”

The post also contains “an email response from lead author, Deborah Bolnick, a biological anthropologist at the University of Texas, to a genetic genealogist who was unhappy with our article.” Dr. Bolnick’s email discusses the eliminated section of the paper and emphasizes that there are a number of genetic genealogists who are very educated in this area of genetics:

“While there are many individuals like you who have learned a great deal about population genetics, the available tests, and the associated population history, there are also a lot of individuals who take these tests without knowing much about them. Our Science article was focused on that group of people because we feel it is important for every test-taker to have a clear understanding of what DNA tests both can and cannot tell us.

Education, as always, is the key.

J. Craig Venter at the Web 2.0 Summit

The Web 2.0 Summit in San Francisco just ended.  One of the first speakers was J. Craig Venter, whose genome was recently sequenced.  He gave a lecture about personalized medicine, personal genetics, and his new book, “A Life Decoded: My Genome, My Life.”

To read more, there’s coverage of his presentation at All Things Digital, Barron’s, Information Week, and The Guardian.