23

GINA: A Primer

dnaa.jpg1. Who is GINA?
GINA isn’t a ‘who’, it’s a ‘what’. GINA stands for Genetic Information Non-Discrimination Act.

2. Okay, what is the Genetic Information Non-Discrimination Act?
GINA aims to protect individuals in a variety of different areas. The legislation would prohibit access to genetic information by insurance companies and would prohibit insurance companies from discriminating against an applicant based on genetic information, the refusal to submit genetic information, or for have been genetically tested in the past. Additionally, the Act would prohibit employers from using or collecting genetic information to make employment decisions. The Act also establishes a Genetic Nondiscrimination Study Commission that is charged with reviewing new developments in the … Click to read more!

DNA Day

dnadaybanner2007.jpgI was unaware that today is actually DNA day.  Learn more here.

“National DNA Day is a unique day where students, teachers and the public can learn more about genetics and genomics! It was created to commemorate the completion of the Human Genome Project in April 2003, and the discovery of DNA’s double helix.

Students and teachers nationwide can celebrate DNA Day and learn more about genetics and genomics through the National DNA Day activities available on these pages. NHGRI offers an online chatroom, a library of webcasts featuring genomic researchers, interactive teaching tools and an opportunity through our Ambassador program to invite a real-life genomic researcher to talk to your … Click to read more!

48

Is Genetic Genealogy A Scam?

If you’re a regular reader of this blog, then you know that I am a strong proponent of genetic testing for genealogical purposes. I believe that when used correctly genetic testing can serve as a valuable tool in the genealogist’s toolbox.
A recent visitor found my blog with the search term “is genetic genealogy a scam?” When I recreated the search, I discovered that a previous post on this blog is the leading link for this search. The process made me think about the many people who are skeptical or wary of genetic genealogy. As a scientist, I appreciate and encourage healthy skepticism. After all, genetic genealogy has been available for less than a decade, and it has changed considerably since it was first offered. I believe that anyone who forays into the … Click to read more!

Genetic Genealogy in the news


This article is appearing in newspapers across the country (In the Rocky Mountain News [Thanks to Tim] and USA Today [Thanks to Megan]).  Martin Marshall never believed that his father was actually his biological father, and testing has shown that he is not related to at least one of his brothers.  Marshall then underwent Y-DNA testing in the hope of learning more about his father’s lineage.
“Marshall logged into an Internet database. He entered his DNA profile, and was astounded to find that virtually every person who closely resembled him genetically was named Sizemore.”
To date, Marshall does not know who his father was, but he is hoping that eventually the mystery will be … Click to read more!

16

Ten Videos for Genetic Genealogists

Want to know more about DNA, DNA replication, and mutations? Here are few videos that I thought might be helpful. Seeing a 3D animation of a biological process can be even more informative than reading about it.

1. DNA Structure I

2. DNA Structure II (a little more technical)

3. DNA Replication

4. PCR – Polymerase Chain Reaction

5. DNA Mutation

6. Genetic Diversity

7. SNPs

8. Haplotypes

9. Mitochondrial DNA Inheritance

10. Mitochondrial Eve:
Click here to view.

And finally, because it’s just too cool not to include:
11. The Inner Workings of the … Click to read more!

8

Faces of Britain

face.jpg

In 2005 the Wellcome Trust established a £2.3 million project (roughly 4.5 million USD) at the University Oxford to examine the genetic makeup of the United Kingdom. The project would be led by the renowned geneticist and Oxford Professor Sir Walter Bodmer, joined by Oxford Professor Peter Donnelly (a population genetics and statistics expert) and the Wellcome Trust Principal Research Fellow Professor Lon Cardon.
The goal of the project is to establish a knowledge base for analyzing genes that are linked to disease. To do this, the researchers hoped to gather DNA from 3000 to 3500 volunteers throughout the UK who live in the same area as their parents and grandparents. Each volunteer’s DNA will be tested for 2000 SNPs (single … Click to read more!

African American Lives 2


Yesterday the producers of last year’s popular PBS series “African American Lives” and “Oprah’s Roots” announced that they are seeking applications from people who are interested in participating in “African American Lives 2.” The producers plan to air the program in February 2008, and it will once again be hosted by Henry Louis Gates Jr. One lucky participant will have their genealogy mapped through a combination of traditional genealogical research and DNA analysis. You can read the full press release here.
Note that applications must be submitted by submitted by 6:00 PM on Friday, May 4, so if you believe that you have “discernible (or at least anecdotal) African ancestry”, as the … Click to read more!

3

Genetic Genealogy Reporting by Non-Scientists – Be Cautious!


The Guardian, a newspaper based in England, recently published an article about genetic genealogy entitled “The appliance of science.” It’s an interesting article that looks at the pros and cons of genetic testing for genealogical purposes.
The journalist quotes Chris Pomery, author of the up-coming book “Family History in the Genes: Trace Your DNA and Grow Your Family Tree.”
“In specific cases, genetics is a very useful tool, but it is not a panacea,” he says. “We’re not even close to the situation where, if you’re starting to research your family history, you should begin with a DNA test. At £100 or so a throw it’s a lot of money, and you can progress your research a long way first for free.”
I agree completely. Genetic genealogy is most useful for researchers that are attempting to verify a … Click to read more!

3

Genetic Genealogy Advice for Newbies, Part II

Yesterday we began to look at an email conversation I had recently with Jasia from The Creative Gene about genetic genealogy.

Jasia began by asking whether she should test both her and her mother’s mtDNA (I advised her no, because they would be the same sequence), and then we talked about testing her father’s mtDNA. Since her father could not be tested directly, Jasia wondered if her brother could provide a sample of her father’s mtDNA. I explained that although her brother could provide a sample of her father’s Y-DNA, she would have to find other sources for her father’s mtDNA, including her father’s sisters or brothers, or the children of her father’s sisters. She responded:
“Fortunately, my dad came from a large family including 6 sisters 4 of which had children. … Click to read more!

8

Genetic Genealogy Advice for Newbies, Part I


This week I had a terrific email conversation with Jasia from The Creative Gene about genetic genealogy. She left a comment on a recent post, Discovering My Maternal Roots, which asked:
“I’m a complete neophyte about DNA for genealogy. I’m wondering if there is any reason to test myself, and my mother. Since the mtDNA seems to trace the maternal line… is it enough to test just one of us or is there something to be learned by testing both of us?”
This is a great question, one that many people who are new to genetic genealogy ask. Understanding how mtDNA and Y-DNA are inherited is one of the most challenging aspects of genetic genealogy. I always think of them as mirror images; if you chart your family tree, the Y-DNA travels down the far left line (from … Click to read more!