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AncestryDNA Recreates Portions of the Genome of David Speegle and his Two Wives

GeneticGenealogyFutureStamp1UPDATE: AncestryDNA scientist Dr. Julie Granka posted about this new development at “AncestryDNA Scientists Achieve Advancement in Human Genome Reconstruction,” and here’s the YouTube video: “AncestryDNA Reconstructs Partial Genome of Person Living 200 Years Ago.”

I’ve written before about a poster presented by AncestryDNA at the American Society of Human Genetics 2013 annual meeting, entitled “Reconstruction of Ancestral Human Genomes from Genome-Wide DNA Matches,” and a poster presented at the 2014 meeting entitled “Reconstruction of ancestral human haplotypes using genetic and genealogical data.” In these posters, the scientists at AncestryDNA revealed their efforts to recreate portions of the genomes of an 18th century couple using sequencing information from hundreds of descendants.

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Recreating a Grandmother’s Genome – Part 2

In my last post (see “Recreating a Grandmother’s Genome – Part 1”), I introduced my grandmother Jane, who died when I was just 8 years old. Although I have only a few memories of my grandmother, I have 25% of her DNA. To explore this rich genetic legacy, I’m trying to recreate as much of my grandmother’s genome as possible using the GEDmatch Tier 1 tool called “Lazarus.”

In the last post we also learned about the new Lazarus tool. In today’s post, we’ll choose what kits to use for my grandmother’s Lazarus kit.

Finding DNA Kits for Lazarus

GROUP 1 – DESCENDANTS ONLY

So GROUP 1 must be descendants of the target Lazarus kit. My grandmother has six children, twelve grandchildren, and eleven great-granchildren. Any of these 29 people are candidates for GROUP 1. Of those 29 people, I’ve tested four of the six children and one of the grandchildren (myself). Yeah, I know, I have more testing to do!

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Recreating a Grandmother’s Genome – Part 1

My grandmother Jane died in 1984 when I was just 8 years old. I have some really great memories of her, faded with time but still filled with emotion. Bath times, spending time with her in the summer, newspaper hats, chrysanthemums.

However, in addition to those memories, she gave me a very unique genetic heritage. She was from a region of the world with a high degree of admixture, and thus it is from her that I obtained my Native American mtDNA, my Native American, African American, and Spanish autosomal DNA. It is an incredibly rich and fascinating genetic legacy.

In an attempt to learn more about my grandmother’s genetic heritage, I’m using GEDmatch’s new Lazarus tool to try to recreate as much of her genome as possible. Join me on the journey, and learn about this new tool.

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Small Matching Segments – Examining Hypotheses

Last week I published “Small Matching Segments – Friend or Foe?” to join in the community’s conversation about the use of “small” segments of DNA, referring to segments 5 cM and smaller (although keep in mind that the term “small,” without a more specific definition, will mean different things to different people).

The question that the community has been struggling with is whether small segments of DNA can be used as genealogical evidence, and if so, how they can be used.

As I wrote in my post, a significant percentage of small segments are false positives, with the number at least 33% and likely much higher. In my examination and in the Durand paper I discuss, a false positive is defined as a small segment that is not shared between a child and at least one of the parents.

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Small Matching Segments – Friend or Foe?

There has been a great deal of conversation in the genetic genealogy community over the past couple of weeks about the use of “small” segments of matching DNA. Typically, the term “small” refers to segments of 5 cM and smaller, although some people include segments of 7 cM or even 10 cM and smaller in the definition.

The question, essentially, is whether small segments of DNA can be used as genealogical evidence, and if so, how they can be used.

While it may seem at first that all shared segments of DNA could constitute genealogical evidence, unfortunately some small segments are IBS, creating “false positive” matches for reasons other than recent ancestry. These segments sometimes match because of lack of phasing, phasing errors, or a variety of other reasons. One thing, however, is clear: there is no debate in the genetic genealogy community that many small segments are false positive matches. There IS debate, however, regarding the rate of false positive matches, and what that means for the use of small segments as genealogical evidence.

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Bridging the Gap Between Traditional Genealogy and Genetic Genealogy at the NYG&B

logo.png  670×83I am incredibly honored to announce my election to the Board of Trustees of the New York Genealogical & Biographical Society! The NYG&B is the largest and oldest genealogical society in New York State, and the second oldest genealogical society in the nation. As a lifelong genealogist with New York roots dating back almost 250 years, joining the NYG&B is a dream come true for me.

Over the past decade, DNA has become a powerful tool for genealogical research. As a member of the NYG&B’s Board of Trustees, I hope to be able to help bridge the (ever-closing) gap between traditional genealogy and genetic genealogy, and help both members and non-members understand and incorporate DNA into their family histories.

The board represents an incredible group of people dedicated to helping people discovery their family histories, and I am so grateful to be able to join them. The full list is below.

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Goodbye False Positives! AncestryDNA Updates its Matching Algorithm

AncestryDNAYesterday, when I checked my AncestryDNA account I had 205 pages of matches, or 10,250 matches in the database. Today, thanks to Ancestry’s new matching algorithm, I have 57 pages of matches, or 2,850 matches in the database (a reduction of 72.2%!). I also have DNA Circles, groups of people who MIGHT share a common ancestor (some of whom share DNA with me).

A New Matching Algorithm

I wrote recently about the new algorithm (see “Finding Genetic Cousins – Separating Fact from Fiction“), as did Judy Russell (“When less is more“) and Roberta Estes (“DNA Day With Ancestry“). In essence, AncestryDNA is leveraging information about allele frequencies (“pile-ups”) in which small IBS segments of DNA shared by many, many people are not utilized for matching.

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Finally! GEDmatch Announces a Monetization Strategy (and a Way to Raise the Dead?)

GEDmatch   Tools for DNA and genealogy researchIf you’re serious about genetic genealogy, you’ve heard of GEDmatch. The third-party site is one of the few ways to compare testing results among the three testing companies. The site

However, since GEDmatch is run by two incredible volunteers (Curtis Rogers and John Olson) with full-time jobs, the site has experienced server issues and downtime. Many have lamented that there was no monetization plan in place, but gave donations in hope that it would help the site grow.

This week, GEDmatch announced a monetization strategy, namely advanced tools that are only available to Tier 1 members at a nominal cost of $10/month:

Basic GEDmatch programs remain free and we plan to keep them this way. Donations help cover the costs associated with running this site, and will provide you with the benefit of using the additional Tier 1 tools for a period of time equal to one month for every $10 donated. You may use the ‘Donate’ button below, for a one-time donation of any amount, or the ‘Join GEDmatch’ button to establish a recurring $10 per month amount.

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Transfer Raw Data to Family Tree DNA for $39 (Sneak Peek for FREE!)

At the Family Tree DNA 10th Annual International Conference, FTDNA announced that they were reducing the price of autosomal DNA transfers (from the AncestryDNA test or the V3 test from 23andMe) from $69 to $39. Additionally, you could upload your raw data for free and you would receive information about your 20 closest matches in the database. On top of that, if you convinced 4 others to transfer their raw data, you would receive a transfer for free!

It looks like the site went live tonight! The link is (www.familytreedna.com/autosomaltransfer).

Here’s what you see at the intro screen:

AutosomalTransfer

autosomaltransfer1

Once you’ve uploaded, you’ll receive an email with a login and password. You’ll then receive a second email a short time later, after your results have been processed. In the meantime, you’ll see this:

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Finding Genetic Cousins – Separating Fact from Fiction

AncestryDNAShort Summary: Before the end of the year, AncestryDNA plans to update our match lists using a new algorithm that reduces the number of false positive matches. For the first time, matching DNA segments will be characterized as IBS (i.e., a false positive) based on something other than simply segment length.

AncestryDNA Day

Last Monday, October 6th, I and six other members of the genetic genealogy community attended a ‘Bloggers Day’ hosted by AncestryDNA at the San Francisco headquarters of Ancestry.com. Two other members of the group have already written about the event:

While at ‘Bloggers Day’ we discussed many issues including the Y-DNA and mtDNA databases originally scheduled for destruction, upcoming changes to AncestryDNA’s matching algorithm (much more below), and other upcoming changes to the AncestryDNA about which you will hopefully soon hear much more.

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